Vangie Cruz (Ina Feleo) is a rebellious woman whose family life and career as a video editor are disrupted when her only brother, a newly ordained priest, Fr. Johnny (Marvin Agustin), is diagnosed of Acute Myeloid Leukemia. As a sibling, Vangie is called upon to be a donor for Fr. Johnny's bone marrow transplant. At first, Vangie is very reluctant. She has a clinical phobia for medical procedures, the reasons for which are rooted in an attempted, but botched, abortion which she suffered through many years earlier and has since been troubled about. Her life is saved by Dr. Joey Lucas (Jomari Yllana) with whom she has a love child, and whom she eventually marries. Vangie's dysfunctional family gravitates around Fr. Johnny, and in their struggle to cope with his illness, find themselves drawn to Ina, begging for her intercession. Their prayers are answered, not so much by way of a miraculous cure for Fr. Johnny, but by the grace of conversion, of love, of forgiveness, reconciliation, and hope.